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KMID : 0379520010170040303
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한국독성학회지
2001 Volume.17 No. 4 p.303 ~ p.308
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Difference of Age-Related Sensitivity to Organophosphates
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Sung Ha-Jung
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Abstract
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The potential for a given anticholinesterase pesticide to exhibit age-related toxicity is essential information for an accurate and proper risk assessment of that compound. This investigation was designed to study the age-related toxicity of active metabolites of four organophosphates using in vitro detoxification measurement. The blood samples were collected from 1 month and 18 months old rats. The IC_{50} values of mouse brain recombinant AChE of chlorpyrifos-oxon, diazoxon, malaoxon and paraoxon were 10.35, 112.84, 151.28 and 18.43 nM, respectively. When the plasma of young rats, and CaCI_2were added, the IC_{50} values of mouse brain recombinant AChE of chlorpyrfos-oxon, diazoxon, malaoxon and paraoxon were 31.89, 164.25, 139.94 and 16.36 nM, respectively. The IC_{50} values of mouse brain recombinant AChE of chlorpyrifos-oxon, diazoxon, malaoxon and paraoxon were changed to 136.840, 1244.45, 654.54 and 52.66 nM by A-esterases In adult rats. These results suggest that four organophosphates have a potential toxicity to exhibit age-related sensitivity.
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KEYWORD
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Organophosphate, Chlorpyrifos, Diazinon, Malathion, Parathion, Carboxylesterase, A-esterase, In vitro detoxication mesurement
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